BCA-1/BLC Mouse Recombinant Protein (CXCL13)

• Description:

  CXCL13 Mouse Recombinant (22-109) produced in E. coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10kDa. The BCA-1 is purified by proprietary chromatographic techniques.

• Synonyms:

  C-X-C motif chemokine 13; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13; Cxcl13; Blc; Scyb13

• Gene Name:

  CXCL13

• UniProt:

  O55038

• Reactivity:

  Mouse

• Tissue Specificity:

  Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles) .

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 97.0% as determined by SDS-PAGE.

• Bioactivity:

  50

• Form:

  Sterile Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  It is recommended to reconstitute the lyophilized CXCL13 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

• Function:

  Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.

• Shipping Conditions:

  Available

• Storage Conditions:

  Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BCA1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.

• Other Gene Names:

  C-X-C motif chemokine 13

• Subcellular Location:

  Secreted.