ILK1 Integrin Linked Kinase Human Recombinant Protein

• Description:

  ILK1 Human Recombinant produced in E. coli is single, a non-glycosylated, Polypeptide chain containing 452 amino acids fragment (1-452) having a molecular mass of 55.92kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The ILK1 is purified by proprietary chromatographic techniques.

• Synonyms:

  Integrin-linked protein kinase; ILK-1; ILK-2; 59 kDa serine/threonine-protein kinase; p59ILK; ILK; ILK1; ILK2; DKFZp686F1765; P59

• Gene Name:

  ILK

• UniProt:

  Q13418

• Reactivity:

  Human

• Tissue Specificity:

  Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

• Source:

  Escherichia coli

• Purification:

  Greater than 95.0% as determined by SDS-PAGE.

• Form:

  Sterile Filtered clear solution.

• Function:

  Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

• Other Gene Names:

  Integrin-linked protein kinase

• Subcellular Location:

  Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium