P85a Phosphoinositide 3-kinase a, regulatory subunit Bovine Recombinant Protein

• Description:

  Phosphoinositide 3-kinase subunit p85a Bovine Recombinant has a molecular weight of 83.5 kDa.

• Synonyms:

  Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase p85 subunit alpha; PtdIns-3-kinase p85-alpha; PI3K; P85a

• Gene Name:

  PIK3R1

• UniProt:

  P23727

• Reactivity:

  Bovine

• Source:

  Leishmania tarentolae

• Purification:

  Greater than 90.0% as determined by SDS-PAGE.

• Form:

  Sterile filtered liquid formualtion.

• Function:

  Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity) .

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) .Avoid multiple freeze-thaw cycles.

• Other Gene Names:

  Phosphatidylinositol 3-kinase regulatory subunit alpha