GM2A GM2 Ganglioside Activator Human Recombinant Protein

• Description:

  GM2A Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain (a.a 33-193) containing 170 amino acids including a 9 a.a N-terminal His tag. The total molecular mass is 18.7kDa (calculated) .

• Synonyms:

  Ganglioside GM2 activator; Cerebroside sulfate activator protein; GM2-AP; Sphingolipid activator protein 3; SAP-3; GM2A

• Gene Name:

  GM2A

• UniProt:

  P17900

• Reactivity:

  Human

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 95.0% as determined by SDS-PAGE.

• Form:

  Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  Prepare about 0.5mg/ml working stock solution with deionized water and let the lyophilized pellet dissolve completely. GM2A is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

• Function:

  The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity) . Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.

• Shipping Conditions:

  Available

• Storage Conditions:

  Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

• Other Gene Names:

  Ganglioside GM2 activator

• Subcellular Location:

  Lysosome.