ATP6AP2 ATPase Transporting Lysosomal Accessory Protein 2 Human Recombinant Protein

• Description:

  ATP6AP2 Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 296 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 33kDa (calculated) .

• Synonyms:

  Renin receptor; ATPase H (+) -transporting lysosomal accessory protein 2; ATPase H (+) -transporting lysosomal-interacting protein 2; ER-localized type I transmembrane adaptor; Embryonic liver differentiation factor 10; N14F; Renin/prorenin receptor; Vacuolar ATP synthase membrane sector-associated protein M8-9; ATP6M8-9; V-ATPase M8.9 subunit; ATP6AP2; ATP6IP2; CAPER; ELDF10; M8-9; MRXE; XMRE; XPDS; HT028; MRXSH; MSTP009; APT6M8-9

• Gene Name:

  ATP6AP2HT028

• UniProt:

  O75787

• Reactivity:

  Human

• Tissue Specificity:

  Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.

• Source:

  Escherichia coli

• Sequence:

  [object Object]

• Purification:

  Greater than 90.0% as determined by SDS-PAGE.

• Form:

  Filtered White lyophilized (freeze-dried) powder.

• Reconstitution:

  Prepare about 0.5mg/ml working stock solution with deionized water and let the lyophilized pellet dissolve completely. ATP6AP2 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

• Function:

  Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) .

• Shipping Conditions:

  Available

• Storage Conditions:

  Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

• Other Gene Names:

  Renin receptor

• Subcellular Location:

  Membrane