Anti-Jarid2 Rabbit Monoclonal Antibody, Carrier-free

Anti-Jarid2 Rabbit Monoclonal Antibody, Carrier-free

• Description: Boster Bio Anti-Jarid2 Rabbit Monoclonal Antibody catalog # M01969. Tested in WB, ICC/IF applications. This antibody reacts with Human.
• Synonyms: Secreted frizzled-related protein 1;FRP-1;sFRP-1;Secreted apoptosis-related protein 2;SARP-2;SFRP1;FRP, FRP1, SARP2;
• Gene Name: Secreted frizzled-related protein 1
• UniProt: Q92833
• Host: Rabbit
• Reactivity: Human
• Immunogen: A synthesized peptide derived from human Jarid2
• Clonality: Monoclonal
• Clone: Clone: 21J42
• Tissue Specificity: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. .
• Applications: WB,ICC,IF
• Purification: Affinity-chromatography
• Concentration: Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
• Form: Liquid
• Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
• Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. .
• Components: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
• Storage Conditions: Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.
• Calculated Molecular Weight: 35386 MW
• Observed Molecular Weight: 139 kDa
• Fragment: IgG
• Applications Notes: WB 1:500-1:2000
  ICC/IF 1:50-1:200
• Subcellular Location: Secreted. Cell membrane or extracellular matrix-associated. Released by heparin-binding.
• Protein Name: Lysosome-associated membrane glycoprotein 2 (Lamp2)