Products for Research Use Only

Big Gastrin - 1, human

CAT: 0013-GTR19067579-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19067579-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Big Gastrin is also referred to as Gastrin-34. Secretion of gastrin is induced by food intake and causes the release of gastric acid in the stom ach. Secreted by the G cells in the gastric mucosa, it is one of the major bioactive forms of gastrin found in tissue and plasma (the other bioactive form is gastrin-17 or little gastrin - Cat# AS-20750) . Both gastrin-17 and gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor. Binding of Gastrin to the CCK2/gastrin receptors on parietal cells of the stomach causes them to secrete hydrochloric acid (HCl) and stimulates lectin-like protein Reg expression via activation of PKC and RhoA. Gastrin also plays a role in release of Histamine and Pepsinogen.
Field of Research
Epigenetics & Chromatin
Purity
≥95%
Molecular Weight
3849.3
Notes
For research use only.
AA Sequence
{Pyr}-LGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF-NH2