Anti-REG1A/1B Antibody Picoband®, Carrier-free

• Background:

  This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.

• Description:

  Boster Bio Anti-REG1A/1B Antibody Picoband® catalog # A03075-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Metastasis-associated protein MTA2; Metastasis-associated 1-like 1; MTA1-L1 protein; p53 target protein in deacetylase complex; MTA2; MTA1L1; PID

• Gene Name:

  metastasis associated 1 family member 2

• Gene ID:

  5967/5968

• UniProt:

  P05451/P48304

• Host:

  Rabbit

• Reactivity:

  Human,Mouse,Rat

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived human REG1A/1B recombinant protein (Position: N51-E90).

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

• Applications:

  WB,ELISA

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Function:

  May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

• Components:

  Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

• References & Citations:

  1. Acquatella-Tran Van Ba, I., Marchal, S., Francois, F., Silhol, M., Lleres, C., Michel, B., Benyamin, Y., Verdier, J.-M., Trousse, F., Marcilhac, A. Regenerating islet-derived 1-alpha (Reg-1-alpha) protein is new neuronal secreted factor that stimulates neurite outgrowth via exostosin tumor-like 3 (EXTL3) receptor. J. Biol. Chem. 287: 4726-4739, 2012. 2. Akiyama, T., Takasawa, S., Nata, K., Kobayashi, S., Abe, M., Shervani, N. J., Ikeda, T., Nakagawa, K., Unno, M., Matsuno, S., Okamoto, H. Activation of Reg gene, a gene for insulin-producing beta-cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation. Proc. Nat. Acad. Sci. 98: 48-53, 2001. 3. Bartoli, C., Gharib, B., Giorgi, D., Sansonetti, A., Dagorn, J.-C., Berge-Lefranc, J.-L. A gene homologous to the reg gene is expressed in human pancreas. FEBS Lett. 327: 289-293, 1993.

• Storage Conditions:

  At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

• Calculated Molecular Weight:

  49162 MW

• Observed Molecular Weight:

  19 kDa

• Fragment:

  Rabbit IgG

• Applications Notes:

  Western blot, 0.25-0.5 μg/ml, Mouse, Rat
  ELISA, 0.1-0.5 μg/ml, -
  

• Subcellular Location:

  Nucleus.

• Protein Name:

  Transcription factor E2F3