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Lentinan

CAT: 0804-HY-N6653Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6653Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lentinan is an orally active biocompatible multifunctional polysaccharide with biological activities such as anti-inflammatory, antioxidant, immune regulation, anti-tumor, hypoglycemic, and lipid-lowering[1][4].
CAS Number
37339-90-5
UNSPSC
12352005
Target
Apoptosis; JAK; Keap1-Nrf2
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lentinan.html
Solubility
0.1 M NaOH : 33.33 mg/mL (ultrasonic; adjust pH to 9 with NaOH) |H2O : 50 mg/mL (ultrasonic)
Smiles
[Lentinan]
References & Citations
[1]Meng M, et al. Lentinan inhibits oxidative stress and alleviates LPS-induced inflammation and apoptosis of BMECs by activating the Nrf2 signaling pathway. Int J Biol Macromol. 2022 Dec 1;222 (Pt B) :2375-2391. |[2]Cui H, et al. Anti-Influenza Effect and Mechanisms of Lentinan in an ICR Mouse Model. Front Cell Infect Microbiol. 2022 May 20;12:892864. |[3]Wang SX, et al. Lentinan ameliorates burn sepsis by attenuating CD4+ CD25+ Tregs. Burns. 2016 Nov;42 (7) :1513-1521. |[4]Chen Q, et al. Upregulation of miR-216a-5p by Lentinan Targeted Inhibition of JAK2/STAT3 Signaling Pathway to Reduce Lung Adenocarcinoma Cell Stemness, Promote Apoptosis, and Slow Down the Lung Adenocarcinoma Mechanisms. Front Oncol. 2021 Nov 25;11:778096. |[5]Ji X, et al. Lentinan improves intestinal inflammation and gut dysbiosis in antibiotics-induced mice. Sci Rep. 2022 Nov 15;12 (1) :19609.|[6]Hu S, et al. Lentinan alleviates diabetic cardiomyopathy by suppressing CAV1/SDHA-regulated mitochondrial dysfunction. Biomed Pharmacother. 2023 Nov;167:115645.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched

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