Anti-Tim 2/Timd2 Antibody Picoband®, FITC Conjugate

• Background:

  Enables ferritin receptor activity. Acts upstream of or within iron ion transport. Located in cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1).

• Description:

  Boster Bio Anti-Tim 2/Timd2 Antibody Picoband® catalog # A32807. Tested in Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Protein Bop; BH3-only protein; Retrotransposon Gag-like protein 10; RTL10; BOP, C22orf29

• Gene Name:

  retrotransposon Gag like 10

• Gene ID:

  171284

• UniProt:

  Q8R183

• Host:

  Rabbit

• Reactivity:

  Mouse,Rat

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  A synthetic peptide corresponding to a sequence at the C-terminus of mouse Tim 2/Timd2, which shares 73.9% amino acid (aa) sequence identity with rat Timd2.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitously expressed.

• Applications:

  WB,IHC,Flow Cytometry

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Function:

  Could induce apoptosis in a BH3 domain-dependent manner. The interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.

• Components:

  Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

• References & Citations:

  1. de Souza, A. J., Oriss, T. B., O'Malley, K. J., Ray, A., Kane, L. P. T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation. Proc. Nat. Acad. Sci. 102: 17113-17118, 2005. 2. Feigelstock, D., Thompson, P., Mattoo, P., Zhang, Y., Kaplan, G. G. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72: 6621-6628, 1998. 3. Ichimura, T., Asseldonk, E. J. P., Humphreys, B. D., Gunaratnam, L., Duffield, J. S., Bonventre, J. V. Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J. Clin. Invest. 118: 1657-1668, 2008.

• Storage Conditions:

  At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

• Calculated Molecular Weight:

  14377 MW

• Observed Molecular Weight:

  70 kDa

• Fragment:

  Rabbit IgG

• Applications Notes:

  Western blot, 0.25-0.5 μg/ml, Mouse
  Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Mouse, Rat
  Immunofluorescence, 5 μg/ml, Mouse
  Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Mouse
  

• Subcellular Location:

  Cell membrane; Lipid-anchor, GPI-anchor.

• Protein Name:

  Lymphocyte antigen 6A-2/6E-1