Anti-Semaphorin 3c/SEMA3C Antibody Picoband®, FITC Conjugate

Anti-Semaphorin 3c/SEMA3C Antibody Picoband®, FITC Conjugate

• Background: Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene. This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease.
• Description: Boster Bio Anti-Semaphorin 3c/SEMA3C Antibody Picoband® catalog # A06444-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
• Synonyms: Semaphorin-3C; Semaphorin-E; Sema E; SEMA3C; SEMAE
• Gene Name: semaphorin 3C
• Gene ID: 10512
• UniProt: Q99985
• Host: Rabbit
• Reactivity: Human,Mouse,Rat
• Cross Reactivity: No cross-reactivity with other proteins.
• Immunogen: E.coli-derived human Semaphorin 3c/SEMA3C recombinant protein (Position: Q24-W674).
• Clonality: Polyclonal
• Tissue Specificity: Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.
• Applications: ELISA,WB
• Purification: Immunogen affinity purified.
• Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
• Form: Lyophilized
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Function: Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.
• Components: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
• References & Citations: 1. Lepore, J. J., Mericko, P. A., Cheng, L., Lu, M. M., Morrisey, E. E., Parmacek, M. S. GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. J. Clin. Invest. 116: 929-939, 2006. 2. Wiegreffe, C., Simon, R., Peschkes, K., Kling, C., Strehle, M., Cheng, J., Srivatsa, S., Liu, P., Jenkins, N. A., Copeland, N. G., Tarabykin, V., Britsch, S. Bcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c. Neuron 87: 311-325, 2015. 
• Storage Conditions: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.
• Observed Molecular Weight: 85 kDa
• Fragment: Rabbit IgG
• Specificity: No cross reactivity with other proteins.
• Applications Notes: Western blot, 0.1-0.5μg/ml
  ELISA, 0.1-0.5μg/ml
  
• Subcellular Location: Secreted.