Raffinose

• Description :

  Raffinose (Melitose) regulates intestinal flora, inhibits TLR4-MyD88-NF-κB signaling pathway, and activates Nrf2 signaling pathway. Raffinose exhibits anti-inflammatory, antioxidant, and immunomodulatory activities. Raffinose is orally active[1][2][3].

• Product Name Alternative :

  Melitose

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; Keap1-Nrf2; MyD88; NF-κB; Toll-like Receptor (TLR)

• Type :

  Natural Products

• Related Pathways :

  Autophagy; Immunology/Inflammation; NF-κB

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/raffinose.html

• Concentration :

  10mM

• Purity :

  98.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 250 mg/mL (ultrasonic)

• Smiles :

  OC[C@]1(O[C@H](CO)[C@@H](O)[C@@H]1O)O[C@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO[C@H]3O[C@@H]([C@H](O)[C@H](O)[C@H]3O)CO

• Molecular Formula :

  C18H32O16

• Molecular Weight :

  504.44

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhang P, et al., Raffinose Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Targeting the Inflammatory TLR4-MyD88-NF-κB Signaling Pathway. Foods. 2024 Jun 13;13 (12) :1849. |[2]Lin S, et al., Raffinose increases autophagy and reduces cell death in UVB-irradiated keratinocytes. J Photochem Photobiol B. 2019 Dec;201:111653. |[3]Liu J, et al., Targeting antioxidant factor Nrf2 by raffinose ameliorates lipid dysmetabolism-induced pyroptosis, inflammation and fibrosis in NAFLD. Phytomedicine. 2024 Jul 25;130:155756.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [512-69-6]