Anti-Carboxypeptidase B2/CPB2 Antibody Picoband® (HRP Conjugate)

• Background:

  Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin/thrombomodulin complex, CPB2 exhibits carboxypeptidase activity. Activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.

• Description:

  Boster Bio Anti-Carboxypeptidase B2/CPB2 Antibody Picoband® catalog # PB9998. Tested in WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Carboxypeptidase B2;3.4.17.20;Carboxypeptidase R;CPR;Carboxypeptidase U;CPU;Thrombin-activable fibrinolysis inhibitor;TAFI;Cpb2;Tafi;

• Gene Name:

  Carboxypeptidase B2

• UniProt:

  Q9JHH6

• Host:

  Rabbit

• Reactivity:

  Mouse

• Cross Reactivity:

  No cross-reactivity with other proteins

• Immunogen:

  E. coli-derived mouse CPB2 recombinant protein (Position: K165-D387). Mouse CPB2 shares 86.1% and 96.9% amino acid (aa) sequence identity with human and rat CPB2, respectively.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Plasma; synthesized in the liver. .

• Applications:

  WB

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down- regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.

• Storage Conditions:

  Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Western blot, 0.1-0.5μg/ml, Mouse
  

• Subcellular Location:

  Secreted .

• Protein Name:

  Carboxypeptidase B2