Acitretin

CAT: 0804-HY-B0107-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0107-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin also can be used for the research of Alzheimer’s disease[1][2][3].
CAS Number
[55079-83-9]
Product Name Alternative
Ro 10-1670
UNSPSC
12352005
Hazard Statement
H315, H319, H360, H410
Target
Apoptosis; Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/acitretin.html
Purity
99.62
Solubility
DMSO : 11.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
CC(/C=C/C(C(C)=CC(OC)=C1C)=C1C)=C\C=C\C(C)=C\C(O)=O
Molecular Formula
C21H26O3
Molecular Weight
326.43
Precautions
H315, H319, H360, H410
References & Citations
[1]Lee CS, et al. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin Pharmacother. 2005 Aug;6 (10) :1725-34.|[2]Sengör B, et al. Effects of acitretin on spermatogenesis of rats. J Eur Acad Dermatol Venereol. 2006 Jul;20 (6) :689-92.|[3]Guilherme MDS, et, al. The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients. Front Aging Neurosci. 2019 Jul 23;11:182.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
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