Acitretin

• Description:

  Acitretin (Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin also can be used for the research of Alzheimer’s disease[1][2][3].

• Product Name Alternative:

  Ro 10-1670

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H360, H410

• Target:

  Apoptosis; Autophagy; RAR/RXR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/acitretin.html

• Purity:

  99.62

• Solubility:

  DMSO : 11.67 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)

• Smiles:

  CC(/C=C/C(C(C)=CC(OC)=C1C)=C1C)=C\C=C\C(C)=C\C(O)=O

• Molecular Formula:

  C21H26O3

• Molecular Weight:

  326.43

• Precautions:

  H315, H319, H360, H410

• References & Citations:

  [1]Lee CS, et al. A review of acitretin, a systemic retinoid for the treatment of psoriasis. Expert Opin Pharmacother. 2005 Aug;6 (10) :1725-34.|[2]Sengör B, et al. Effects of acitretin on spermatogenesis of rats. J Eur Acad Dermatol Venereol. 2006 Jul;20 (6) :689-92.|[3]Guilherme MDS, et, al. The Synthetic Retinoid Acitretin Increases IL-6 in the Central Nervous System of Alzheimer Disease Model Mice and Human Patients. Front Aging Neurosci. 2019 Jul 23;11:182.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• CAS Number:

  [55079-83-9]