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Corticostatin-14

CAT: 0013-GTR19067631-01Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19067631-01Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cortistatin 14 is an endogenous neuropeptide, mainly expressed in the cortex and hippocampus, that has structural and functional similarities to somatostatin-14. Cortistatin 14 displays potency at all somatostatin receptors (sst1 - sst5) and prevents somatostatin-14 binding (IC50 values are 0.09, 0.2, 0.3, 0.3 and 5 nM at sst2, sst4, sst3, sst5 and sst1 receptors, respectively) . Also a potent MRGPRX2 agonist (EC50 = 25 nM in HEK293 cells) and binds to the growth hormone secretagog receptor (GHS-R1a) . Exhibits neuronal depressant and sleep-modulating properties in vivo.
Purity
≥95%
Molecular Weight
1721
Notes
For research use only.
AA Sequence
PCKNFFWKTFSSCK (Disulfide bridge: 2-13)

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