Products for Research Use Only
RegisterLogin

Izuforant

CAT: 0804-HY-147276-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-147276-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Izuforant (JW1601) (Compound 24) is an orally active histamine H4 receptor (H4R) antagonist with an IC50 of 36 nM against human H4R. Izuforant also shows binding affinity of human serotonin 3 receptor (h5-HT3R) with an IC50 of 9.1 μM. Izuforant exhibits strong anti-pruritic and anti-inflammatory efficacies[1][2].
CAS Number
1429374-83-3
Product Name Alternative
JW1601
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/izuforant.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CNC1CN(C2=NC3=NC=C(Br)C=C3N4C2=NN=C4)C1
Molecular Formula
C12H12BrN7
Molecular Weight
334.17
References & Citations
[1]Pil Su Ho, et al. Novel heterocyclic derivatives and their uses. WO2013048214A2.|[2]Jin M, et al. From Bench to Clinic: the Potential of Therapeutic Targeting of the IL-22 Signaling Pathway in Atopic Dermatitis. Immune Netw. 2018 Dec 19;18 (6) :e42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H4 Receptor

Alternative Products

CatalogName
GTR19187547-01Izuforant
CS-O-47109N-Nitroso Izuforant

Popular Products