Cyclothiazide

• Description:

  Cyclothiazide is a positive allosteric modulator of ionotropic AMPA-type glutamate receptors. Cyclothiazide inhibits GABAA receptors. Cyclothiazide is frequently used to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Cyclothiazide can potentiate responses to kainate in hippocampal neurons. Cyclothiazide has effects on glutamatergic neurotransmission. Cyclothiazide also induces epileptiform EEG activity accompanying behavioral seizures[1][2][3][4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  GABA Receptor; iGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cyclothiazide.html

• Purity:

  98.78

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=S(C1=C(Cl)C=C(C2=C1)NC(C3C(C4)C=CC4C3)NS2(=O)=O)(N)=O

• Molecular Formula:

  C14H16ClN3O4S2

• Molecular Weight:

  389.88

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Fucile S, et al. Effects of cyclothiazide on GluR1/AMPA receptors. Proc Natl Acad Sci U S A. 2006;103 (8) :2943-2947. |[2]Patneau, D. K., et al., (1993) . Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. The Journal of neuroscience: the official journal of the Society for Neuroscience, 13 (8), 3496–3509.|[3]Partin, K. M., et al., (1993) . Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron, 11 (6), 1069–1082.|[4]Qi, J., et al., (2006) . Cyclothiazide induces robust epileptiform activity in rat hippocampal neurons both in vitro and in vivo. The Journal of physiology, 571 (Pt 3), 605–618.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  AMPA Receptor

• CAS Number:

  [2259-96-3]