WEE1-IN-5

WEE1-IN-5

• CAS Number: 2243882-74-6
• UNSPSC Description: WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer[1].
• Target Antigen: CDK; Wee1
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/wee1-in-5.html
• Solubility: DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C1C2=CN=C(NC3=CC=C(C4CCN(CC4)C)C(C)=C3)N=C2N(CN1C5=C(Cl)C=CC=C5Cl)C
• Molecular Weight: 511.45
• References & Citations: [1]H. Gelderblom, et al. 601TiP First-in-human phase I study of a novel oral Wee1 inhibitor (Debio 0123) in combination with carboplatin in patients with advanced solid tumours. Ann Oncol. 2020 Sep; 31: S501-S502.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported