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3- (3-Hydroxyphenyl) propionic acid

CAT: 0804-HY-W005255-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W005255-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3- (3-Hydroxyphenyl) propionic acid (3HPPA) is an endothelium-dependent nitric oxide (NO) release promoter and endothelial nitric oxide synthase (eNOS) activator. 3- (3-Hydroxyphenyl) propionic acid activates eNOS to mediate vascular smooth muscle relaxation and enhances endothelial cell NO synthesis, inducing vasodilation and reducing peripheral vascular resistance. 3- (3-Hydroxyphenyl) propionic acid can dose-dependently reduce systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR) without affecting cardiac contractility or heart rate. 3- (3-Hydroxyphenyl) propionic acid has antihypertensive and vascular protective effects and can be used in the prevention and treatment of cardiovascular diseases[1].
CAS Number
621-54-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/3-3-hydroxyphenyl-propionic-acid.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCC1=CC=CC(O)=C1
Molecular Formula
C9H10O3
Molecular Weight
166.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Najmanová I, et al. Flavonoid metabolite 3- (3-hydroxyphenyl) propionic acid formed by human microflora decreases arterial blood pressure in rats. Mol Nutr Food Res. 2016 May;60 (5) :981-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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