Ondansetron

CAT: 0804-HY-B0002B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0002B-01Size:5 mg
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Description
Ondansetron (GR 38032; SN 307) is a highly selective 5-HT3 receptor antagonist with an IC50 value of 103 pM. Ondansetron exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron can inhibit nausea and vomiting induced by chemotherapy and radiotherapy[1][2][3][4][5][6][7][8].
CAS Number
[99614-02-5]
Product Name Alternative
GR 38032; SN 307
UNSPSC
12352005
Hazard Statement
H301, H318
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ondansetron.html
Purity
99.46
Solubility
DMSO : 10 mg/mL (ultrasonic)
Smiles
O=C1C(CN2C=CN=C2C)CCC(N3C)=C1C4=C3C=CC=C4
Molecular Formula
C18H19N3O
Molecular Weight
293.36
Precautions
H301, H318
References & Citations
[1]Brown AM, et al. Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT3A) . J Physiol. 1998 Mar 15;507 (Pt 3) :653-65.|[2]Barann M, et al. Recombinant human 5-HT3A receptors in outside-out patches of HEK 293 cells: basic properties and barbiturate effects. Naunyn Schmiedebergs Arch Pharmacol. 2000 Sep;362 (3) :255-65.|[3]Wildeboer KM, et al. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009 Dec 1;1300:41-50.|[4]Khedhaier A, et al. Circadian rhythms in toxic effects of the serotonin antagonist ondansetron in mice. Chronobiol Int. 2003 Nov;20 (6) :1103-16.|[5]Umathe SN, et al. The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice. Behav Pharmacol. 2009 Feb;20 (1) :78-83.|[6]Doggrell SA, et al. Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia. Expert Opin Drug Saf. 2013 May;12 (3) :421-31.|[7]Xin Wang, et al. Effectiveness of Olanzapine Combined with Ondansetron in Prevention of Chemotherapy-Induced Nausea and Vomiting of Non-small Cell Lung Cancer. Cell Biochem Biophys. 2015 Jun;72 (2) :471-3.|[8]Azadeh Motavallian-Naeini, et al. Anti-inflammatory effect of ondansetron through 5-HT3 receptors on TNBS-induced colitis in rat. EXCLI J2012 Feb 22:11:30-44. eCollection 2012.|[9]허원석. Effects of ondansetron on the activity of glutamate transporter type 3 and the modulation mechanism[D]. 서울대학교 대학원, 2014.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Lactoferrin
Citation 01
Adv Sci (Weinh) . 2025 Apr 7:e2503739.|Biochem Biophys Res Commun. 2025 Oct 30:786:152756.|Front Pharmacol. 2024 Aug 21:15:1443169.|J Ethnopharmacol. 2024 Apr 6:323:117703.|J Radiat Res Appl Sci. 2023 Dec, 16 (4), 100682.|Prog Neuropsychopharmacol Biol Psychiatry. 2023 Mar 2:122:110689.|SSRN. 2023 Srep 5.|Eur J Pharm Sci. 2023 Aug 1:187:106475.|Int J Pharm. 2015 Dec 30;496 (1) :33-41.|Patent. US20170319486A1.

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