Lurasidone

CAT: 0804-HY-B0032A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0032A-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
CAS Number
[367514-87-2]
Product Name Alternative
SM-13496
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Lurasidone.html
Purity
99.36
Solubility
DMSO : 20.83 mg/mL (ultrasonic) |Ethanol : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C([C@H]1[C@H]2C[C@H](CC2)[C@@H]31)N(C[C@H](CCCC4)[C@@H]4CN5CCN(CC5)C6=NSC7=CC=CC=C67)C3=O
Molecular Formula
C28H36N4O2S
Molecular Weight
492.68
Precautions
H302, H315, H319, H335
References & Citations
[1]Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334 (1) :171-81.|[2]Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4) : 931-937.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor;5-HT7 Receptor; D2 Receptor; mLAG-3; MUC3
Citation 01
Antibiotics (Basel) . 2024 Mar 28;13 (4) :308.|bioRxiv. 2024 Jan 14.|bioRxiv. 2025 Sep 9.|J Med Chem. 2024 Apr 25;67 (8) :6144-6188.|J Ocul Pharmacol Ther. 2024 Oct;40 (8) :536-542.|Marmara Pharm J. 2017;21 (4) : 931-937.|Marmara Pharm J. 2017;21 (4) : 931-937.|Nat Immunol. 2025 May;26 (5) :722-736.|Nature. 2023 Dec;624 (7992) :672-681.|ACS Chem Neurosci. 2020 Jan 15;11 (2) :173-183.|Marmara Pharm J. 2017;21 (4) : 931-937.|Physiol Behav. 2026 Feb:304:115176.

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