Anti-LAMP1 Antibody Picoband® (Biotine Conjugate)

• Background:

  LAMP1 (lysosomal-associated membrane protein 1) also called LAMPA, LGP120 or CD107A, is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells. By means of in situ hybridization, Mattei et al. (1990) assigned the LAMP1 gene to chromosome 13q34. A related gene, which may be a pseudogene, mapped to chromosome 12p13.3. Hybridization of LAMP1 cDNA to chromosome 12p13.3 was observed even when probes representing different portions of the LAMP1 cDNA were used.

• Description:

  Boster Bio Anti-LAMP1 Antibody catalog # PA1822. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Lysosome-associated membrane glycoprotein 1;LAMP-1;Lysosome-associated membrane protein 1;CD107 antigen-like family member A;CD107a;LAMP1;

• Gene Name:

  Lysosome-associated membrane glycoprotein 1

• UniProt:

  P11279

• Host:

  Rabbit

• Reactivity:

  Human,Mouse

• Cross Reactivity:

  No cross-reactivity with other proteins

• Immunogen:

  A synthetic peptide corresponding to a sequence at the C-terminus of human LAMP1, different from the related mouse and rat sequences by one amino acid.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in breast, ovary and prostate.

• Applications:

  WB

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

• Storage Conditions:

  Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Western blot, 0.1-0.5μg/ml, Human, Mouse
  

• Subcellular Location:

  Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome. This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome.

• Sequence Similarities:

  Belongs to the peptidase S1 family. Kallikrein subfamily.

• Protein Name:

  Lysosome-associated membrane glycoprotein 1(LAMP-1)