Anti-Dopamine Receptor D5/DRD5 Antibody Picoband®

• Background:

  D (1B) dopamine receptor (DRD5), also called DRD1B or DRD1L2 is a protein that in humans is encoded by the DRD5 gene. This gene is mapped to 4p16.1. This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. Compared with DRD1, DRD5 displayed a higher affinity for dopamine and was able to stimulate a biphasic rather than a monophasic intracellular accumulation of cAMP.

• Description:

  Boster Bio Anti-Dopamine Receptor D5/DRD5 Antibody catalog # PA2204. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  D (1B) dopamine receptor; D (5) dopamine receptor; Dopamine D5 receptor; Drd5

• Gene Name:

  D (1B) dopamine receptor

• UniProt:

  Q8BLD9

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Cross Reactivity:

  No cross-reactivity with other proteins

• Immunogen:

  A synthetic peptide corresponding to a sequence at the C-terminus of mouse Dopamine Receptor D5, different from the related rat sequence by two amino acids, and from the related human sequence by three amino acids.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Brain, liver, placenta, lymphocytes and erythrocytes.

• Applications:

  WB

• Field of Research:

  Cancer, Cancer Metabolism, G Protein Signaling, Metabolism, Neuroscience, Neurotransmission, Neurotransmitter, Receptors / Channels, Signal Transduction, Signaling Pathway

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. .

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Western blot, 0.1-0.5μg/ml, Mouse, Rat
  

• Other Gene Names:

  DRD5

• Subcellular Location:

  Cell membrane; Multi-pass membrane protein.

• Sequence Similarities:

  Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family.

• Protein Name:

  D (1B) dopamine receptor