Anti-TrkC/NTRK3 Antibody Picoband®

• Background:

  NTRK3 (Neurotrophic Tyrosine Kinase Receptor Type 3), also known as TRKC, is a protein that in humans is encoded by the NTRK3 gene. By PCR analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization with the cDNA clone, McGregor et al. (1994) mapped the NTRK3 gene to 15q24-q25. Lamballe et al. (1991) isolated and characterized TRKC, a member of the TRK family of tyrosine protein kinase genes. They found that TRKC is preferentially expressed in the brain; in situ hybridization studies showed transcripts in the hippocampus, cerebral cortex, and the granular cell layer of the cerebellum. By functional studies in HeLa cells, Muinos-Gimeno et al. (2009) demonstrated that 5 miRNAs regulate the truncated form of NTRK3.

• Description:

  Boster Bio Anti-TrkC/NTRK3 Antibody catalog # PA1992. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  NT-3 growth factor receptor;2.7.10.1; GP145-TrkC; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; NTRK3; TRKC

• Gene Name:

  NT-3 growth factor receptor

• UniProt:

  Q16288

• Host:

  Rabbit

• Reactivity:

  Rat, Mouse, Human

• Cross Reactivity:

  No cross-reactivity with other proteins

• Immunogen:

  A synthetic peptide corresponding to a sequence at the N-terminus of human TrkC, different from the related rat and mouse sequences by three amino acids.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.

• Applications:

  WB

• Field of Research:

  Cancer, Growth and Development, Metabolism, Metabolism Processes, Neurology Process, Neuroscience, Oncoproteins, Oncoproteins/Suppressors, Pathways and Processes

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Receptor for neurotrophin-3 (NT-3) . This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
  

• Other Gene Names:

  NTRK3

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Sequence Similarities:

  Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

• Protein Name:

  NT-3 growth factor receptor