Anti-SOX10 Antibody Picoband®

• Background:

  Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

• Description:

  Boster Bio Anti-SOX10 Antibody Picoband® catalog # A00758-3. Tested in ELISA, IF, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Transcription factor SOX-10; SOX10

• Gene Name:

  SRY-box 10

• UniProt:

  P56693

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived human SOX10 recombinant protein (Position: R178-L301) .

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in fetal brain and in adult brain, heart, small intestine and colon.

• Applications:

  WB, ICC, IF, Flow Cytometry, ELISA

• Field of Research:

  Cell Type Marker, Developmental Biology, Domain Families, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Neuroscience, Stem Cells, Transcription

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Function:

  Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) . .

• Storage Conditions:

  At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

• Fragment:

  Rabbit IgG

• Applications Notes:

  6

• Other Gene Names:

  SOX10

• Subcellular Location:

  Cytoplasm. Nucleus.