Anti-Desmoplakin/DSP Antibody Picoband®

• Background:

  Desmoplakin is a protein in humans that is encoded by the DSP gene. This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants.

• Description:

  Boster Bio Anti-Desmoplakin/DSP Antibody Picoband® catalog # A00616-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Desmoplakin; DP; 250/210 kDa paraneoplastic pemphigus antigen; DSP

• Gene Name:

  Desmoplakin

• UniProt:

  P15924

• Host:

  Rabbit

• Reactivity:

  Human

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived human Desmoplakin/DSP recombinant protein (Position: N69-H2195) .

• Clonality:

  Polyclonal

• Tissue Specificity:

  Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin.

• Applications:

  ELISA, Flow Cytometry, WB

• Field of Research:

  Calcium Binding Proteins, Calcium Signaling, Cell Biology, Cell Cycle, Cell Differentiation, Cytoskeleton/ECM, Developmental Biology, ECM Proteins, Extracellular Matrix, Organogenesis, Signal Transduction, Signaling Pathway, Skeletal Development, Structures

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Function:

  Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.

• Storage Conditions:

  At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

• Fragment:

  Rabbit IgG

• Applications Notes:

  6

• Other Gene Names:

  DSP

• Subcellular Location:

  Cell junction, desmosome.

• Protein Name:

  Steroid 17-alpha-hydroxylase/17,20 lyase