Anti-Eotaxin/Ccl11 Antibody

• Background:

  CCL11 (Chemokine (C-C motif) ligand 11), also known as Eotaxin, is a small cytokine belonging to the CC chemokine family. Eotaxin selectively recruits eosinophils by inducing their chemotaxis, and therefore, is implicated in allergic responses. The effects of Eotaxin are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for which Eotaxin is a ligand include CCR2, CCR3 and CCR5. However, it has been found that eotaxin-1 (CCL11) has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3. The gene for human Eotaxin is encoded on three exons and is located on chromosome 17q12.

• Description:

  Boster Bio Anti-Eotaxin/Ccl11 Antibody Picoband® catalog # A01438-2. Tested in ELISA, IHC applications. This antibody reacts with Rat.

• Synonyms:

  Bestrophin-1; TU15B; Vitelliform macular dystrophy protein 2; BEST1; VMD2

• Gene Name:

  Bestrophin 1

• UniProt:

  P97545

• Host:

  Rabbit

• Reactivity:

  Rat

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived rat Eotaxin/Ccl11 recombinant protein (Position: H24-P97) .

• Clonality:

  Polyclonal

• Tissue Specificity:

  Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.

• Applications:

  IHC, ELISA

• Field of Research:

  Cell Adhesion Proteins, ECM Proteins, Neuroscience, Sensory System, Visual System

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Function:

  Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.

• Storage Conditions:

  At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Rat
  ELISA, 0.1-0.5 μg/ml, Rat
  

• Other Gene Names:

  Ccl11

• Subcellular Location:

  Cell membrane.

• Protein Name:

  Keratin, type I cytoskeletal 14