Anti-CD97/Adgre5 Antibody Picoband®

• Background:

  Cluster of differentiation 97 is a protein also known as BL-Ac[F2] encoded by the ADGRE5 gene. This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.

• Description:

  Boster Bio Anti-CD97/Adgre5 Antibody Picoband® catalog # A30392-1. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  C-C motif chemokine 6; Protein C10; Small-inducible cytokine A6; CCL6 (22-95) ; CCL6 (23-95) ; Ccl6; C10; Scya6

• Gene Name:

  Chemokine (C-C motif) ligand 6

• UniProt:

  Q9Z0M6

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived mouse CD97/Adgre5 recombinant protein (Position: Q287-S816) .

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in myelopoietic bone marrow cultures stimulated by GM-CSF.

• Applications:

  WB, IHC, Flow Cytometry, ELISA

• Field of Research:

  Chemokines, Immunology, Innate Immunity

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  CCL6 (22-95) and CCL6 (23-95) are potent chemoattractants.

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  6

• Other Gene Names:

  Adgre5

• Subcellular Location:

  Secreted.

• Protein Name:

  Large S protein