Anti-CINP Antibody Picoband®

• Background:

  Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene. The protein encoded by this gene is reported to be a component of the DNA replication complex as well as a genome-maintenance protein. It may interact with proteins important for replication initiation and has been shown to bind chromatin at the G1 phase of the cell cycle and dissociate from chromatin with replication initiation. It may also serve to regulate checkpoint signaling as part of the DNA damage response. Alternative splicing results in multiple transcript variants.

• Description:

  Boster Bio Anti-CINP Antibody Picoband® catalog # A07687-1. Tested in Flow Cytometry, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Trem-like transcript 1 protein; TLT-1; Triggering receptor expressed on myeloid cells-like protein 1; TREML1; TLT1; UNQ1825/PRO3438

• Gene Name:

  Trem-like transcript 1 protein

• UniProt:

  Q9D0V8

• Host:

  Rabbit

• Reactivity:

  Mouse

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  A synthetic peptide corresponding to a sequence at the N-terminus of mouse CINP, which shares 85.7% and 100% amino acid (aa) sequence identity with human and rat CINP, respectively.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Detected in platelets, monocytic leukemia and in T-cell leukemia. .

• Applications:

  WB, Flow Cytometry

• Field of Research:

  Cardiovascular, Immunology, Innate Immunity, Macrophage/Inflammation, Platelets, Protein Phosphorylation, Signal Transduction

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Cell surface receptor that may play a role in the innate and adaptive immune response. .

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  6

• Other Gene Names:

  Cinp

• Subcellular Location:

  Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151) . Transported to the cell surface after stimulation by thrombin (PubMed:15100151) . Soluble fragments can be released into the serum by proteolysis (PubMed:16505478) .

• Protein Name:

  Trem-like transcript 1 protein