Anti-PDE6 alpha/PDE6A Antibody Picoband®

• Background:

  This gene encodes the cyclic-GMP (cGMP) -specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

• Description:

  Boster Bio Anti-PDE6 alpha/PDE6A Antibody Picoband® catalog # A07800-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Protein SOX-15; Protein SOX-12; Protein SOX-20; SOX15; SOX12; SOX20; SOX26; SOX27

• Gene Name:

  SRY-box 15

• UniProt:

  P16499

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived human PDE6 alpha/PDE6A recombinant protein (Position: K11-R237) .

• Clonality:

  Polyclonal

• Tissue Specificity:

  Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.

• Applications:

  WB, IHC, ICC, IF, Flow Cytometry, ELISA

• Field of Research:

  Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Binds to the 5'-AACAAT-3' sequence.

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  6

• Other Gene Names:

  PDE6A

• Subcellular Location:

  Nucleus.

• Protein Name:

  Chromaffin granule amine transporter