Anti-Growth hormone receptor/GHR Picoband® Antibody

• Background:

  Growth hormone receptor is a protein that in humans is encoded by the GHR gene. It is mapped to 15 A1; 15 1.84 cM. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.

• Description:

  Boster Bio Anti-Growth hormone receptor/GHR Picoband® Antibody catalog # A00698-1. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Growth hormone receptor; GH receptor; Somatotropin receptor; Growth hormone-binding protein; GH-binding protein; GHBP; Serum-binding protein; Ghr

• Gene Name:

  Growth hormone receptor

• UniProt:

  P16882

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E.coli-derived mouse Growth hormone receptor/GHR recombinant protein (Position: T25-Q650) .

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in lung and placenta.

• Applications:

  WB, Flow Cytometry, ELISA

• Field of Research:

  Cancer, Cell Cycle, DNA/RNA, Epigenetics and Nuclear Signaling, Kinases/Phosphatases, Nuclear Import/Export, Protein Trafficking, RNA Processing, Signal Transduction

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  6

• Other Gene Names:

  Ghr

• Subcellular Location:

  Cell membrane. Single-pass type I membrane protein. Secreted.