Anti-CHX10/VSX2 Antibody Picoband®

• Background:

  Visual system homeobox 2 is a protein that in humans is encoded by the VSX2 gene. This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. In situ hybridization to human fetal retinal sections detected CHX10 expression in retinal neuroblasts at all stages examined. Human CHX10 is expressed in progenitor cells of the developing neuroretina and in the inner nuclear layer of the mature retina.

• Description:

  Boster Bio Anti-CHX10/VSX2 Antibody Picoband® catalog # A05180. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  Visual system homeobox 2; Ceh-10 homeodomain-containing homolog; Homeobox protein CHX10; VSX2; CHX10, HOX10

• Gene Name:

  Visual system homeobox 2

• UniProt:

  P58304

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Cross Reactivity:

  No cross-reactivity with other proteins.

• Immunogen:

  E. coli-derived human CHX10 recombinant protein (Position: A249-A361) . Human CHX10 shares 90.3% amino acid (aa) sequence identity with mouse CHX10.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate.

• Applications:

  WB

• Field of Research:

  2339, Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Sensory System, Visual System

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity) . .

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Western blot, 0.1-0.5μg/ml, Mouse, Human
  

• Other Gene Names:

  VSX2

• Subcellular Location:

  Nucleus.

• Protein Name:

  Long-chain-fatty-acid--CoA ligase 5