Anti-C Reactive Protein/Crp Antibody Picoband®

• Background:

  C Reactive Protein (CRP) is a major acute phase reactant synthesized primarily in the liver hepatocytes. It is composed of 5 identical, 21,500-molecular weight subunits. CRP mediates activities associated with preimmune nonspecific host resistance. CRP shows the strongest association with cardiovascular events. It is detectable on the surface of about 4% of normal peripheral blood lymphocytes. Acute phase reactant CRP is produced in the liver.

• Description:

  Boster Bio Anti-C Reactive Protein/Crp Antibody Picoband® catalog # A00249-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

• Synonyms:

  C-reactive protein; Crp; Ptx1

• Gene Name:

  C-reactive protein

• UniProt:

  P14847

• Host:

  Rabbit

• Reactivity:

  Mouse, Rat

• Cross Reactivity:

  No cross-reactivity with other proteins

• Immunogen:

  E. coli-derived mouse Crp recombinant protein (Position: H20-S225) . Mouse Crp shares 71.9% and 72.7% amino acid (aa) sequence identity with human and rat Crp, respectively.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Found in plasma.

• Applications:

  ELISA, IHC, WB

• Field of Research:

  Apoptosis, Atherosclerosis, Cardiovascular, Chromatin Binding Proteins, Complement, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Macrophage/Inflammation, Metabolism, Vascular Inflammation

• Purification:

  Immunogen affinity purified.

• Concentration:

  Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

• Function:

  Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Mouse, Rat, By Heat
  ELISA, 0.1-0.5μg/ml, -
  Western blot, 0.1-0.5μg/ml, Rat, Mouse
  

• Other Gene Names:

  Crp

• Subcellular Location:

  Secreted.

• Protein Name:

  C-reactive protein