Flumethasone

CAT: 0804-HY-B1051-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1051-01Size:50 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-κB) -mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction) . Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation[1][2][3][4].
CAS Number
[2135-17-3]
Product Name Alternative
Flumetasone
UNSPSC
12352211
Hazard Statement
H351
Target
Glucocorticoid Receptor; Interleukin Related; Keap1-Nrf2; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Flumethasone.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@](C(CO)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
Molecular Formula
C22H28F2O5
Molecular Weight
410.45
Precautions
H351
References & Citations
[1]Zhou Y, et al. Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway. Cancer Lett. 2020 Apr 1;474:94-105.|[2]Blake RL. Flumethasone induction of liver tyrosine aminotransferase activity in inbred strains and obese mutant mice. Biochem Pharmacol. 1970 May;19 (5) :1803-15.|[3]Bednarek D, et al. The effect of steroidal and non-steroidal anti-inflammatory drugs on the cellular immunity of calves with experimentally-induced local lung inflammation. Vet Immunol Immunopathol. 1999 Oct 1;71 (1) :1-15.|[4]Willi RA, et al. Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos. Sci Total Environ. 2019 Jul 1;672:183-191.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

Related Products

CatalogName

Alternative Products

CatalogName
GA2414-1gFlumethasone
MBS3615934-01Flumethasone pivalate
sc-396067Flumethasone Acetate
bs-71036RFlumethasone antibody
012115Flumethasone-d3
MBS5304052-01Flumethasone-HRP

Popular Products