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6-Methoxyflavanone

CAT: 0804-HY-N8852-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N8852-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6-Methoxyflavanone (6-MeOF) is a flavonoid compound that can cross the blood-brain barrier. 6-Methoxyflavanone is a positive allosteric modulator of GABAA receptors. 6-Methoxyflavanone exhibits positive allosteric regulatory effects on human recombinant α1β2γ2L and α2β2γ2L GABAA receptors, and is relatively inactive on the α1β2 GABAA receptor. 6-Methoxyflavanone showes inhibitory behavior towards the activation of bitter receptor hTAS2R39 and hTAS2R14, demonstrating a reversible and non-overcome antagonistic effect. 6-Methoxyflavanone has the effects of anti-anxiety, analgesia and relief of neuropathic pain[1][2][3][4].
CAS Number
3034-04-6
Product Name Alternative
6-MeOF
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor; Taste Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/6-methoxyflavanone.html
Purity
98.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1CC(C2=CC=CC=C2)OC3=CC=C(OC)C=C13
Molecular Formula
C16H14O3
Molecular Weight
254.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Akbar S, et al. Characterization of 6-methoxyflavanone as a novel anxiolytic agent: A behavioral and pharmacokinetic approach. Eur J Pharmacol. 2017 Apr 15;801:19-27.|[2]Akbar S, et al. 6-Methoxyflavanone attenuates mechanical allodynia and vulvodynia in the streptozotocin-induced diabetic neuropathic pain. Biomed Pharmacother. 2016 Dec;84:962-971.|[3]Roland WS, et al. 6-methoxyflavanones as bitter taste receptor blockers for hTAS2R39. PLoS One. 2014 Apr 10;9 (4) :e94451.|[4]Hall BJ, et al. Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone. Neurochem Res. 2014 Jun;39 (6) :1068-78.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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