Biotinylated Monoclonal Anti-FMC63 Antibody, Mouse IgG1, Avitag™ (Y45)

Biotinylated Monoclonal Anti-FMC63 Antibody, Mouse IgG1, Avitag™ (Y45)

• Background: FMC63 is an IgG2a mouse monoclonal antibody specific for CD19, which is a target for the immunotherapy of B lineage leukaemias and lymphomas. FMC63 scFv is the most commonly used ectodomain component of CD19-specific CARs. So far, most of reported CART19 trials contain the anti-CD19 scFv derived from FMC63, including the two FDA-approved CARs Kymriah and Yescarta.
• Description: Monoclonal Anti-FMC63 Antibody, Mouse IgG1, Avitag™ (Y45) is a mouse monoclonal antibody recombinantly expressed from human 293 cells (HEK293). Biotinylation of this antibody is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
• CAS Number: 9007-83-4
• Host: HEK 293
• Origin Species: Mouse
• Target: FMC63
• Conjugation: Biotin-labeled
• Tag: Mouse IgG1 & C-Avi | kappa
• Applications: Flow Cytometry (Evaluation of Anti-CD19 (FMC63 scFv) CAR Expression).
• Stability: -20°C to -70°C for 24 months in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower._x000D_Please avoid repeated freeze-thaw cycles.
• Format: Powder
• Buffer: PBS, 0.5% BSA, pH7.4
• Additives: Trehalose
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C