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GRP-60367 (hydrochloride)

CAT: 0804-HY-133735A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-133735A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein[1].
CAS Number
2803211-60-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RABV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/grp-60367-hydrochloride.html
Purity
99.41
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC1=C(OCCNC2CCN(C(C3=CC=NC=C3)=O)CC2)C=C(C)C=C1.[H]Cl
Molecular Formula
C21H28ClN3O2
Molecular Weight
389.92
Precautions
H302, H315, H319, H335
References & Citations
[1]Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94 (13) :e00321-20.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

GRP-60367 (hydrochloride)
CAS Number2803211-60-9
PubChem CID155291570
IUPAC Name[4-[2-(2,5-dimethylphenoxy)ethylamino]piperidin-1-yl]-pyridin-4-ylmethanone;hydrochloride
Molecular FormulaC21H28ClN3O2
Molecular Weight389.9
Topological Polar Surface Area54.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity431
SMILES
CC1=CC(=C(C=C1)C)OCCNC2CCN(CC2)C(=O)C3=CC=NC=C3.Cl
InChI
InChI=1S/C21H27N3O2.ClH/c1-16-3-4-17(2)20(15-16)26-14-11-23-19-7-12-24(13-8-19)21(25)18-5-9-22-10-6-18;/h3-6,9-10,15,19,23H,7-8,11-14H2,1-2H3;1H
InChIKey
OOJFZGBROIVYNL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of GRP-60367 (hydrochloride)
CAS: 2803211-60-9
CID: 155291570
Formula: C21H28ClN3O2
MW: 389.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight389.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass389.1870048
Monoisotopic Mass389.1870048
Topological Polar Surface Area54.5 Ų
Heavy Atom Count27
Formal Charge0
Complexity431
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

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GTR19154191-01GRP-60367 hydrochloride
555848GRP-60367
A22169-1GRP-60367 1mg
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A22169-50GRP-60367 50mg
A22169-200GRP-60367 200mg
A22169-10GRP-60367 10mg
A22169-5GRP-60367 5mg
A22169-100GRP-60367 100mg
A22169-25GRP-60367 25mg

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