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Alpha-cobratoxin

CAT: 0466-CBT001Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0466-CBT001Size:0.1 mg
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Description
α-cobratoxin (alpha-elapitoxin-Nk2a) has been isolated from the venom of the Naja kaouthia cobra snake. α-cobratoxin preferentially blocks muscular and neuronal α 7/CHRNA7 nicotinic acetylcholine receptor (Kd = 55 pM) . α-cobratoxin is involved in paralysis by preventing acetylcholine binding to the nAChR. This toxin has shown to cause reduction of tumor growth in mice lung cancer.
CAS Number
769933-79-1
Specifications
α7 nicotinic acetylcholine receptor (nAChR) antagonist
Target
Acetylcholine receptors
Sequence
IRCFITPDITSKDCPNGHVCYTKTWCDAFCSIRGKRVDLGCAATCPTVKTGVDIQCCSTDNCNPFPTRKRP
Peptide Number
CBT001
Disulfide Bonds
Cys3-Cys20; Cys14-Cys41; Cys26-Cys30; Cys45-Cys56; Cys57-Cys62
N Terminal Sequence
H
C Terminal Sequence
OH

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