Alpha-cobratoxin

• Description:

  α-cobratoxin (alpha-elapitoxin-Nk2a) has been isolated from the venom of the Naja kaouthia cobra snake. α-cobratoxin preferentially blocks muscular and neuronal α 7/CHRNA7 nicotinic acetylcholine receptor (Kd = 55 pM) . α-cobratoxin is involved in paralysis by preventing acetylcholine binding to the nAChR. This toxin has shown to cause reduction of tumor growth in mice lung cancer.

• Specifications:

  α7 nicotinic acetylcholine receptor (nAChR) antagonist

• Target:

  Acetylcholine receptors

• Sequence:

  IRCFITPDITSKDCPNGHVCYTKTWCDAFCSIRGKRVDLGCAATCPTVKTGVDIQCCSTDNCNPFPTRKRP

• Peptide Number:

  CBT001

• Disulfide Bonds:

  Cys3-Cys20; Cys14-Cys41; Cys26-Cys30; Cys45-Cys56; Cys57-Cys62

• N Terminal Sequence:

  H

• C Terminal Sequence:

  OH

• CAS Number:

  769933-79-1