Idazoxan (hydrochloride)
CAT:
804-HY-14561A-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Idazoxan (hydrochloride)
- CAS Number: 79944-56-2
- UNSPSC Description: Idazoxan hydrochloride (RX 781094 hydrochloride) is an α2-adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinson’s disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism[1][2].
- Target Antigen: Adrenergic Receptor; Imidazoline Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Neuronal Signaling
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Neurological Disease; Endocrinology
- Assay Protocol: https://www.medchemexpress.com/idazoxan-hydrochloride.html
- Solubility: DMSO : 116.67 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
- Smiles: [H]Cl.C1(C2OC3=CC=CC=C3OC2)=NCCN1
- Molecular Weight: 240.69
- References & Citations: [1]Roberto W Invernizzi, et al. The α2-Adrenoceptor Antagonist Idazoxan Reverses Catalepsy Induced by Haloperidol in Rats Independent of Striatal Dopamine Release: Role of Serotonergic Mechanisms. Neuropsychopharmacology volume 28, pages872-879 (2003).|[2]Bousquet P, et al. Participation of imidazoline receptors and alpha(2-)-adrenoceptors in the central hypotensive effects of imidazoline-like drugs. Ann N Y Acad Sci. 1999 Jun 21;881:272-8.
- Shipping Conditions: Room Temperature
- Clinical Information: Phase 3