Anti-TG beta 1 TGFB1 Monoclonal Antibody

• Description:

  Boster Bio Anti-TG beta 1 TGFB1 Monoclonal Antibody catalog # M00019-2. Tested in ELISA, WB applications. This antibody reacts with Human.

• Synonyms:

  Transforming growth factor beta-1; TGF-beta-1; Latency-associated peptide; LAP; TGFB1; TGFB;

• Gene Name:

  TGFB1

• UniProt:

  P01137

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Purified recombinant fragment of TGFbeta1 expressed in E. Coli.

• Clonality:

  Monoclonal

• Clone:

  Clone: 4F9C10 / 1B11B7

• Tissue Specificity:

  Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA) . Colocalizes with ASPN in chondrocytes within OA lesions of articular cartilage.

• Applications:

  WB, ELISA

• Purification:

  Affinity purification

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity) . Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401) . Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292) . Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292) .

• Molecular Weight:

  44341 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Transforming growth factor beta-1

• Subcellular Location:

  Secreted, extracellular space, extracellular matrix

• Protein Name:

  Transforming growth factor beta-1