Anti-MEK-4 MAP2K4 Monoclonal Antibody

• Description:

  Boster Bio Anti-MEK-4 MAP2K4 Monoclonal Antibody catalog # M01725. Tested in ELISA, IHC applications. This antibody reacts with Human.

• Synonyms:

  Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4;2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKK; MAP2K4; JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1;

• Gene Name:

  MAP2K4

• UniProt:

  P45985

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Purified recombinant fragment of MEK-4 expressed in E. Coli.

• Clonality:

  Monoclonal

• Clone:

  Clone: 2D10D8 / 4G11B2 / 2D10C4 / 2D10C3

• Tissue Specificity:

  Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

• Applications:

  IHC, ELISA

• Purification:

  Affinity purification

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

• Molecular Weight:

  44288 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgM

• Other Gene Names:

  Dual specificity mitogen-activated protein kinase kinase 4

• Subcellular Location:

  Cytoplasm . Nucleus .

• Protein Name:

  Dual specificity mitogen-activated protein kinase kinase 4