Anti-DDR2 Monoclonal Antibody

• Description:

  Boster Bio Anti-DDR2 Monoclonal Antibody catalog # M01698-1. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human.

• Synonyms:

  Discoidin domain-containing receptor 2; Discoidin domain receptor 2;2.7.10.1; CD167 antigen-like family member B; Discoidin domain-containing receptor tyrosine kinase 2; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD167b; DDR2; NTRKR3, TKT, TYRO10;

• Gene Name:

  DDR2

• UniProt:

  Q16832

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Purified recombinant fragment of human DDR2 expressed in E. Coli.

• Clonality:

  Monoclonal

• Clone:

  Clone: 3B11E4

• Tissue Specificity:

  Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level) . Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.

• Applications:

  WB, IHC, IF, ELISA

• Purification:

  Affinity purification

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

• Molecular Weight:

  96736 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Discoidin domain-containing receptor 2

• Subcellular Location:

  Cell membrane

• Protein Name:

  Discoidin domain-containing receptor 2