Anti-HIF-1 beta/ARNT Monoclonal Antibody

• Description:

  Boster Bio Anti-HIF-1 beta/ARNT Monoclonal Antibody catalog # M02263-1. Tested in IHC, WB applications. This antibody reacts with Mouse.

• Synonyms:

  Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta; ARNT; BHLHE2;

• Gene Name:

  ARNT

• UniProt:

  P27540

• Host:

  Mouse

• Reactivity:

  Mouse

• Immunogen:

  Recombinant Protein of HIF-1 β

• Clonality:

  Monoclonal

• Clone:

  Clone: 4C5

• Applications:

  WB, IHC

• Purification:

  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity) . The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28396409) .

• Molecular Weight:

  86636 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Aryl hydrocarbon receptor nuclear translocator

• Subcellular Location:

  Nucleus.

• Protein Name:

  Aryl hydrocarbon receptor nuclear translocator