Anti-TNF alpha Monoclonal Antibody

• Description:

  Boster Bio Anti-TNF alpha Monoclonal Antibody catalog # M00002-3. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; Tumor necrosis factor, membrane form; N-terminal fragment; NTF; Intracellular domain 1; ICD1; Intracellular domain 2; ICD2; C-domain 1; C-domain 2; Tumor necrosis factor, soluble form; TNF; TNFA, TNFSF2;

• Gene Name:

  TNF

• UniProt:

  P01375

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic Peptide of TNF α

• Clonality:

  Monoclonal

• Clone:

  Clone: Q34

• Applications:

  IHC, WB

• Purification:

  The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208) . Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918) .

• Molecular Weight:

  25644 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Tumor necrosis factor

• Subcellular Location:

  Cell membrane

• Protein Name:

  Tumor necrosis factor