Anti-TERT Antibody

• Description:

  Boster Bio Anti-TERT Antibody catalog # A00012-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.

• Synonyms:

  Telomerase reverse transcriptase;2.7.7.49

• Gene Name:

  TERT

• UniProt:

  O14746

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  The antiserum was produced against synthesized peptide derived from the C-terminal region of human TERT. AA range:931-980

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed at a high level in thymocyte subpopulations, at an intermediate level in tonsil T-lymphocytes, and at a low to undetectable level in peripheral blood T- lymphocytes.

• Applications:

  WB, IHC, ELISA

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3'-chromosomal termini with the 6- nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.

• Molecular Weight:

  126997 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Telomerase reverse transcriptase

• Subcellular Location:

  Nucleus, nucleolus

• Protein Name:

  Telomerase reverse transcriptase