Anti-SETMAR Antibody

Boster Bio Anti-SETMAR Antibody catalog # A04944-1. Tested in ELISA, IHC applications. This antibody reacts with Human.

Histone-lysine N-methyltransferase SETMAR ; SET domain and mariner transposase fusion protein ; Metnase

SETMAR

Q53H47

Human

The antiserum was produced against synthesized peptide derived from human SETMAR. AA range:350-400

Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.

IHC, ELISA

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid

Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842) . In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448) . Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750) .

78034 MW

Available

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

IgG

Histone-lysine N-methyltransferase SETMAR

Nucleus