Anti-NMD epsilon GRIN2C Antibody

• Description:

  Boster Bio Anti-NMD epsilon GRIN2C Antibody catalog # A07769. Tested in ELISA, IHC applications. This antibody reacts with Human.

• Synonyms:

  Glutamate receptor ionotropic, NMDA 2C; GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C; GRIN2C; NMDAR2C;

• Gene Name:

  GRIN2C

• UniProt:

  Q14957

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human NMDAepsilon3. AA range:937-986

• Clonality:

  Polyclonal

• Tissue Specificity:

  Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.

• Applications:

  IHC, ELISA

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg (2+) (PubMed:26875626) . Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable) . Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity) .

• Molecular Weight:

  134209 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Glutamate receptor ionotropic, NMDA 2C

• Subcellular Location:

  Cell membrane

• Protein Name:

  Glutamate receptor ionotropic, NMDA 2C