Anti-GPR124 ADGRA2 Antibody

• Description:

  Boster Bio Anti-GPR124 ADGRA2 Antibody catalog # A09540-1. Tested in ELISA, IF, WB applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Adhesion G protein-coupled receptor A2 ; G-protein coupled receptor 124

• Gene Name:

  ADGRA2

• UniProt:

  Q96PE1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human GPR124. AA range:1151-1200

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628) . Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905) .

• Applications:

  WB, IF, ELISA

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314) . Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity) . Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher- order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314) . ADGRA2- tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314) . Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628) .

• Molecular Weight:

  142647 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  Adhesion G protein-coupled receptor A2

• Subcellular Location:

  Cell membrane

• Protein Name:

  Adhesion G protein-coupled receptor A2