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Anti-E2F-6 Antibody

CAT: 0519-A05062-1Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0519-A05062-1Size:100 µL
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Description
Boster Bio Anti-E2F-6 Antibody catalog # A05062-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Synonyms
Transcription factor E2F6; E2F-6; E2F6;
Gene Name
E2F6
UniProt
O75461
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human E2F6. AA range:141-190
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues examined. Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen.
Applications
WB, IHC, ELISA
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Molecular Weight
31844 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Transcription factor E2F6
Subcellular Location
Nucleus.
Protein Name
Transcription factor E2F6