Anti-HER2 (Phospho-Tyr1139) ERBB2 Antibody

• Description:

  Boster Bio Anti-HER2 (Phospho-Tyr1139) ERBB2 Antibody catalog # A00010Y1139. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Receptor tyrosine-protein kinase erbB-2;2.7.10.1; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD340; ERBB2; HER2, MLN19, NEU, NGL;

• Gene Name:

  ERBB2

• UniProt:

  P04626

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from human HER2 (Phospho-Tyr1139)

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

• Applications:

  IHC, WB

• Purification:

  The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  IHC-p 1:50-200, WB 1:500-2000

• Form:

  Liquid

• Function:

  Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs) . Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. .

• Molecular Weight:

  137910 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Receptor tyrosine-protein kinase erbB-2

• Subcellular Location:

  Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.

• Protein Name:

  Receptor tyrosine-protein kinase erbB-2